Neuroendocrinology of the skin.
Rev Endocr Metab Disord
; 17(3): 287-294, 2016 09.
Article
en En
| MEDLINE
| ID: mdl-27338934
ABSTRACT
The skin is considered the mirror of the soul and is affected by neurohormonal triggers, especially stress. Hair follicles, keratinocytes, mast cells, melanocytes, and sebocytes all express sex and stress hormones implicating them in a local "hypothalamic-pituitary-adrenal axis." In particular, the peptides corticotropin-releasing hormone (CRH) and neurotensin (NT) have synergistic action stimulating mast cells and are uniquely elevated in the serum of patients with skin diseases exacerbated by stress. Addressing the neurohormonal regulation of skin function could lead to new targets for effective treatment of inflammatory skin diseases.
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Bases de datos:
MEDLINE
Asunto principal:
Sistema Hipófiso-Suprarrenal
/
Enfermedades de la Piel
/
Estrés Psicológico
/
Hormona Liberadora de Corticotropina
/
Neurotensina
/
Sistema Hipotálamo-Hipofisario
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Rev Endocr Metab Disord
Asunto de la revista:
ENDOCRINOLOGIA
/
METABOLISMO
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos