N-linked glycosylation of Kv1.2 voltage-gated potassium channel facilitates cell surface expression and enhances the stability of internalized channels.

Thayer, Desiree A; Yang, Shi-Bing; Jan, Yuh Nung; Jan, Lily Y

Thayer, Desiree A; Yang, Shi-Bing; Jan, Yuh Nung; Jan, Lily Y.

Afiliación

Thayer DA; Howard Hughes Medical Institute, Departments of Physiology, Biochemistry and Biophysics, Kavli Institute for Fundamental Neuroscience, Weill Institute for Neurosciences, University of California-San Francisco, San Francisco, CA, USA.
Yang SB; Amunix, Mountain View, CA, USA.
Jan YN; Howard Hughes Medical Institute, Departments of Physiology, Biochemistry and Biophysics, Kavli Institute for Fundamental Neuroscience, Weill Institute for Neurosciences, University of California-San Francisco, San Francisco, CA, USA.
Jan LY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

J Physiol ; 594(22): 6701-6713, 2016 11 15.

Article en En | MEDLINE | ID: mdl-27377235

Asunto(s)

Membrana Celular/metabolismo; Canal de Potasio Kv.1.2/metabolismo; Canales de Potasio con Entrada de Voltaje/metabolismo; Animales; Células COS; Línea Celular; Chlorocebus aethiops; Femenino; Glicosilación; Neuronas/metabolismo; Polisacáridos/metabolismo; Embarazo; Transporte de Proteínas/fisiología; Ratas; Ratas Sprague-Dawley

Palabras clave

channel stability; channel trafficking; glycosylation; potassium channel; voltage-gated channels

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Membrana Celular / Canales de Potasio con Entrada de Voltaje / Canal de Potasio Kv.1.2 Límite: Animals / Pregnancy Idioma: En Revista: J Physiol Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos

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