Pharyngeal constrictor muscle fatty change may contribute to obstructive sleep apnea-hypopnea syndrome: a prospective observational study.
Acta Otolaryngol
; 136(12): 1285-1290, 2016 Dec.
Article
en En
| MEDLINE
| ID: mdl-27399965
ABSTRACT
CONCLUSIONS:
Pharyngeal constrictor muscle injury and fatty changes may play important roles in the pathogenesis and progression of OSAHS.OBJECTIVE:
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a respiratory disorder caused by upper airway obstruction during sleep. The primary objectives of this study were to determine the ultrastructural characteristics of the pharyngeal constrictor muscle in patients with OSAHS.METHODS:
A pharyngeal constrictor muscle specimen was collected from all subjects. The muscle cell ultrastructure was observed under electron microscopy.RESULTS:
Eighteen male patients with OSAHS (OSAHS group) and 10 male body mass index-matched patients with chronic tonsillitis (control group) were enrolled in this study. All patients were obese adults. The apnea-hypopnea index (41.22 ± 17.29 vs 2.30 ± 1.10 events/h) was significantly higher and the lowest arterial oxygen saturation (76.00 ± 8.57% vs 97.00 ± 2.00%) was significantly lower in the OSAHS group than in the control group (both p < 0.001). Myofibril disorder, mitochondrial edema, and intramyocellular lipid droplets were observed in patients with OSAHS. There was a significant correlation between the number of lipid droplets and the apnea-hypopnea index.Palabras clave
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Bases de datos:
MEDLINE
Asunto principal:
Músculos Faríngeos
/
Apnea Obstructiva del Sueño
/
Gotas Lipídicas
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Acta Otolaryngol
Año:
2016
Tipo del documento:
Article