Evaluating the clinical relevance of a cognitive composite outcome measure: An analysis of 1414 participants from the 5-year GuidAge Alzheimer's prevention trial.
Alzheimers Dement
; 12(12): 1216-1225, 2016 12.
Article
en En
| MEDLINE
| ID: mdl-27423962
ABSTRACT
INTRODUCTION:
Composite cognitive scores have been developed as primary outcome measures for preclinical/prevention trials for Alzheimer's disease (AD), mainly using observational data and with little consideration of clinical relevance.METHODS:
Secondary analysis of placebo group data from a 5-year AD prevention trial. The composite score was the average of the following z scores MMSE orientation items, Free and Cued Selective Reminding Test, Category Fluency, Trail Making Test-part B.RESULTS:
Composite score change from baseline differed significantly by age, APOE genotype, and CDR progression and AD dementia status. A 1 point decrease in baseline score was highly predictive of 5-year AD dementia risk (HR = 3.51, 95% CI, 2.62-4.71, P < .001). The 1 year minimum clinically important difference was estimated at -0.3 points and predicted AD dementia.DISCUSSION:
We explored the clinical relevance of a composite score in a prevention trial setting. This type of analysis facilitates the interpretation of composite scores and informs power calculations.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Cognición
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Enfermedad de Alzheimer
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Pruebas Neuropsicológicas
Tipo de estudio:
Evaluation_studies
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Observational_studies
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Prognostic_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Alzheimers Dement
Año:
2016
Tipo del documento:
Article