A Novel Population of Wake-Promoting GABAergic Neurons in the Ventral Lateral Hypothalamus.
Curr Biol
; 26(16): 2137-43, 2016 08 22.
Article
en En
| MEDLINE
| ID: mdl-27426511
ABSTRACT
The largest synaptic input to the sleep-promoting ventrolateral preoptic area (VLPO) [1] arises from the lateral hypothalamus [2], a brain area associated with arousal [3-5]. However, the neurochemical identity of the majority of these VLPO-projecting neurons within the lateral hypothalamus (LH), as well as their function in the arousal network, remains unknown. Herein we describe a population of VLPO-projecting neurons in the LH that express the vesicular GABA transporter (VGAT; a marker for GABA-releasing neurons). In addition to the VLPO, these neurons also project to several other established sleep and arousal nodes, including the tuberomammillary nucleus, ventral periaqueductal gray, and locus coeruleus. Selective and acute chemogenetic activation of LH VGAT(+) neurons was profoundly wake promoting, whereas acute inhibition increased sleep. Because of its direct and massive inputs to the VLPO, this population may play a particularly important role in sleep-wake switching.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Vigilia
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Expresión Génica
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Proteínas del Transporte Vesicular de Aminoácidos Inhibidores
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Neuronas GABAérgicas
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Área Hipotalámica Lateral
Límite:
Animals
Idioma:
En
Revista:
Curr Biol
Asunto de la revista:
BIOLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos