A newly synthesized macakurzin C-derivative attenuates acute and chronic skin inflammation: The Nrf2/heme oxygenase signaling as a potential target.

Akram, Muhammad; Shin, Iljin; Kim, Kyeong-A; Noh, Dabi; Baek, Seung-Hoon; Chang, Sun-Young; Kim, Hyoungsu; Bae, Ok-Nam

Akram, Muhammad; Shin, Iljin; Kim, Kyeong-A; Noh, Dabi; Baek, Seung-Hoon; Chang, Sun-Young; Kim, Hyoungsu; Bae, Ok-Nam.

Afiliación

Akram M; College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Republic of Korea.
Shin I; College of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, Suwon, Republic of Korea.
Kim KA; College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Republic of Korea.
Noh D; College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Republic of Korea.
Baek SH; College of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, Suwon, Republic of Korea.
Chang SY; College of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, Suwon, Republic of Korea.
Kim H; College of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, Suwon, Republic of Korea. Electronic address: hkimajou@ajou.ac.kr.
Bae ON; College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Republic of Korea. Electronic address: onbae@hanyang.ac.kr.

Toxicol Appl Pharmacol ; 307: 62-71, 2016 09 15.

Article en En | MEDLINE | ID: mdl-27450019

Asunto(s)

Antiinflamatorios/farmacología; Antiinflamatorios/uso terapéutico; Flavonoides; Enfermedad Aguda; Animales; Línea Celular; Enfermedad Crónica; Dermatitis Atópica/tratamiento farmacológico; Dermatitis Atópica/metabolismo; Dinoprostona/metabolismo; Flavonoides/química; Flavonoides/farmacología; Flavonoides/uso terapéutico; Hemo-Oxigenasa 1/metabolismo; Humanos; Interferón gamma/farmacología; Lipopolisacáridos; Masculino; Ratones; Ratones Endogámicos BALB C; Ratones Endogámicos ICR; Factor 2 Relacionado con NF-E2/metabolismo; FN-kappa B/metabolismo; Óxido Nítrico/metabolismo; Oxazolona; Células RAW 264.7; Acetato de Tetradecanoilforbol; Factor de Necrosis Tumoral alfa/farmacología

Palabras clave

Anti-inflammatory activity; Oxazolone-induced atopic dermatitis; Synthetic flavonoid; TPA-induced acute inflammation

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Flavonoides / Antiinflamatorios Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Toxicol Appl Pharmacol Año: 2016 Tipo del documento: Article

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