IL-4 and IL-15 promotion of virtual memory CD8+ T cells is determined by genetic background.
Eur J Immunol
; 46(10): 2333-2339, 2016 10.
Article
en En
| MEDLINE
| ID: mdl-27457412
ABSTRACT
Virtual memory (VM) CD8+ T cells are present in unimmunized mice, yet possess T-cell receptors specific for foreign antigens. To date, VM cells have only been characterized in C57BL/6 mice. Here, we assessed the cytokine requirements for VM cells in C57BL/6 and BALB/c mice. As reported previously, VM cells in C57BL/6 mice rely mostly on IL-15 and marginally on IL-4. In stark contrast, VM cells in BALB/c mice rely substantially on IL-4 and marginally on IL-15. Further, NKT cells are the likely source of IL-4, because CD1d-deficient mice on a BALB/c background have significantly fewer VM cells. Notably, this NKT/IL-4 axis contributes to appropriate effector and memory T-cell responses to infection in BALB/c mice, but not in C57BL/6 mice. However, the effects of IL-4 are manifest prior to, rather than during, infection. Thus, cytokine-mediated control of the precursor population affects the development of virus-specific CD8+ T-cell memory. Depending upon the genetic background, different cytokines encountered before infection may influence the subsequent ability to mount primary and memory anti-viral CD8+ T-cell responses.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Subgrupos de Linfocitos T
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Interleucina-4
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Infecciones por Arenaviridae
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Linfocitos T CD8-positivos
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Interleucina-15
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Memoria Inmunológica
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Virus de la Coriomeningitis Linfocítica
Límite:
Animals
Idioma:
En
Revista:
Eur J Immunol
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos