123I-FP-CIT SPECT findings and its clinical relevance in prodromal dementia with Lewy bodies.
Eur J Nucl Med Mol Imaging
; 44(3): 358-365, 2017 Mar.
Article
en En
| MEDLINE
| ID: mdl-27480759
ABSTRACT
PURPOSE:
Evidence for the prodromal stage of dementia with Lewy bodies (DLB) is very limited. To address this issue, we investigate the 123I-FP-CIT SPECT measure of dopamine transporter binding finding and its clinical relevance.METHODS:
We enrolled subjects into a prodromal DLB group (PRD-DLB) (n = 20) and clinical DLB group (CLIN-DLB) (n = 18) and compared these groups with an Alzheimer's disease control group (AD) (n = 10). PRD-DLB was defined as patients having the non-motor symptoms associated with Lewy body disease (LBD) [i.e. REM sleep behavior disorder (RBD), olfactory dysfunction, autonomic dysfunction, and depression] and showing characteristic diffuse occipital hypometabolism in 18F-FDG PET. CLIN-DLB was defined as patients fulfilling the established criteria of probable DLB. Striatal specific binding ratio (SBR) of 123I-FP-CIT SPECT was used for objective group comparisons. The correlations between SBR and cognitive function (MMSE), motor symptoms (UPDRS3), and duration of LBD-associated non-motor symptoms were compared between the two DLB groups.RESULTS:
Mean SBR scores of both PRD-DLB and CLIN-DLB were significantly lower than those of AD. No correlation was found between SBR and MMSE scores. Both in the CLIN-DLB and total DLB groups, SBR scores were negatively correlated with UPDRS3 scores, whereas no correlation was found in PRD-DLB. Among the LBD-related non-motor symptoms, duration of olfactory dysfunction, and RBD demonstrated negative correlation with SBR scores in PRD-DLB.CONCLUSION:
123I-FP-CIT SPECT may play a role for detecting DLB among the subjects in prodromal stage. During this stage, long-term olfactory dysfunction and/or RBD may indicate more severe degeneration of the nigro-striatal dopaminergic pathway.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Tropanos
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Tomografía Computarizada de Emisión de Fotón Único
/
Radiofármacos
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Enfermedad por Cuerpos de Lewy
Tipo de estudio:
Diagnostic_studies
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Evaluation_studies
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Screening_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Eur J Nucl Med Mol Imaging
Asunto de la revista:
MEDICINA NUCLEAR
Año:
2017
Tipo del documento:
Article
País de afiliación:
Japón