The effect of blood pressure on non-invasive fractional flow reserve derived from coronary computed tomography angiography.
Eur Radiol
; 27(4): 1416-1423, 2017 Apr.
Article
en En
| MEDLINE
| ID: mdl-27541354
ABSTRACT
OBJECTIVES:
The aim of this study is to assess the effect of blood pressure (BP) on coronary computed tomography angiography (CTA) derived computational fractional flow reserve (CTA-FFR). MATERIALS ANDMETHODS:
Twenty-one patients who underwent coronary CTA and invasive FFR were retrospectively identified. Ischemia was defined as invasive FFR ≤0.80. Using a work-in-progress computational fluid dynamics algorithm, CTA-FFR was computed with BP measured before CTA, and simulated BPs of 60/50, 90/60, 110/70, 130/80, 150/90, and 180/100 mmHg respectively. Correlation between CTA-FFR and invasive FFR was assessed using Pearson test. The repeated measuring test was used for multiple comparisons of CTA-FFR values by simulated BP inputs.RESULTS:
Twenty-nine vessels (14 with invasive FFR ≤0.80) were assessed. The average CTA-FFR for measured BP (134 ± 20/73 ± 12 mmHg) was 0.77 ± 0.12. Correlation between CTA-FFR by measured BP and invasive FFR was good (r = 0.735, P < 0.001). For simulated BPs of 60/50, 90/60, 110/70, 130/80, 150/90, and 180/100 mmHg, the CTA-FFR increased 0.69 ± 0.13, 0.73 ± 0.12, 0.75 ± 0.12, 0.77 ± 0.11, 0.79 ± 0.11, and 0.81 ± 0.10 respectively (P < 0.05).CONCLUSION:
Measurement of the BP just before CTA is preferred for accurate CTA-FFR simulation. BP variations in the common range slightly affect CTA-FFR. However, inaccurate BP assumptions differing from the patient-specific BP could cause misinterpretation of borderline significant lesions. KEY POINTS ⢠The blood pressure (BP) affects the CTA-FFR computation. ⢠Measured BP before CT examination is preferable for accurate CTA-FFR simulation. ⢠Inaccurate BP assumptions can cause misinterpretation of borderline significant lesions.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Presión Sanguínea
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Enfermedad de la Arteria Coronaria
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Angiografía Coronaria
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Reserva del Flujo Fraccional Miocárdico
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Angiografía por Tomografía Computarizada
Tipo de estudio:
Observational_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Eur Radiol
Asunto de la revista:
RADIOLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Japón