Endothelial STAT3 Activation Increases Vascular Leakage Through Downregulating Tight Junction Proteins: Implications for Diabetic Retinopathy.

Yun, Jang-Hyuk; Park, Sung Wook; Kim, Kyung-Jin; Bae, Jong-Sup; Lee, Eun Hui; Paek, Sun Ha; Kim, Seung U; Ye, Sangkyu; Kim, Jeong-Hun; Cho, Chung-Hyun

Yun, Jang-Hyuk; Park, Sung Wook; Kim, Kyung-Jin; Bae, Jong-Sup; Lee, Eun Hui; Paek, Sun Ha; Kim, Seung U; Ye, Sangkyu; Kim, Jeong-Hun; Cho, Chung-Hyun.

Afiliación

Yun JH; Department of Pharmacology and Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Park SW; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Kim KJ; Department of Biomedical Sciences, Seoul National University College of Medicine, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
Bae JS; Fight Against Angiogenesis-Related Blindness Laboratory, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
Lee EH; Department of Pharmacology and Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Paek SH; College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, Republic of Korea.
Kim SU; Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Ye S; Department of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea.
Kim JH; Medical Research Institute, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.
Cho CH; Department of Pharmacology and Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.

J Cell Physiol ; 232(5): 1123-1134, 2017 05.

Article en En | MEDLINE | ID: mdl-27580405

Asunto(s)

Retinopatía Diabética/metabolismo; Retinopatía Diabética/patología; Regulación hacia Abajo; Células Endoteliales/metabolismo; Ocludina/metabolismo; Vasos Retinianos/patología; Factor de Transcripción STAT3/metabolismo; Proteína de la Zonula Occludens-1/metabolismo; Animales; Línea Celular; Permeabilidad de la Membrana Celular; Regulación hacia Abajo/efectos de los fármacos; Células Endoteliales/efectos de los fármacos; Células Endoteliales/patología; Glucosa/toxicidad; Humanos; Interleucina-6/metabolismo; Masculino; Ratones Endogámicos C57BL; Microglía/efectos de los fármacos; Microglía/metabolismo; Especies Reactivas de Oxígeno/metabolismo; Retina/efectos de los fármacos; Retina/patología; Vasos Retinianos/efectos de los fármacos; Regulación hacia Arriba/efectos de los fármacos; Factor A de Crecimiento Endotelial Vascular/metabolismo

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Vasos Retinianos / Regulación hacia Abajo / Células Endoteliales / Retinopatía Diabética / Factor de Transcripción STAT3 / Ocludina / Proteína de la Zonula Occludens-1 Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: J Cell Physiol Año: 2017 Tipo del documento: Article

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