Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses.

Wu, Wenxin; Zhang, Wei; Booth, J Leland; Hutchings, David C; Wang, Xiaoqiu; White, Vicky L; Youness, Houssein; Cross, Cory D; Zou, Ming-Hui; Burian, Dennis; Metcalf, Jordan P

Wu, Wenxin; Zhang, Wei; Booth, J Leland; Hutchings, David C; Wang, Xiaoqiu; White, Vicky L; Youness, Houssein; Cross, Cory D; Zou, Ming-Hui; Burian, Dennis; Metcalf, Jordan P.

Afiliación

Wu W; Pulmonary and Critical Care Division, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Zhang W; Pulmonary and Critical Care Division, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Booth JL; Pulmonary and Critical Care Division, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Hutchings DC; Cherokee Healthcare Services, Catoosa, OK, USA.
Wang X; Pulmonary and Critical Care Division, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
White VL; Civil Aerospace Medical Institute, Federal Aviation Administration, Oklahoma City, OK, USA.
Youness H; Pulmonary and Critical Care Division, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Cross CD; Pulmonary and Critical Care Division, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Zou MH; Center of Molecular and Translational Medicine, Georgia State University, Atlanta, GA, USA.
Burian D; Civil Aerospace Medical Institute, Federal Aviation Administration, Oklahoma City, OK, USA.
Metcalf JP; Pulmonary and Critical Care Division, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. jordan-metcalf@ouhsc.edu.

Respir Res ; 17(1): 111, 2016 09 07.

Article en En | MEDLINE | ID: mdl-27604339

Asunto(s)

Bronquios/virología; Metilación de ADN; Epigénesis Genética; Células Epiteliales/virología; Subtipo H1N1 del Virus de la Influenza A/patogenicidad; Gripe Humana/genética; Gripe Humana/virología; Fumar/genética; Bronquios/efectos de los fármacos; Bronquios/metabolismo; Células Cultivadas; Proteína 58 DEAD Box/genética; Proteína 58 DEAD Box/metabolismo; Metilación de ADN/efectos de los fármacos; Metilasas de Modificación del ADN/antagonistas & inhibidores; Metilasas de Modificación del ADN/metabolismo; Inhibidores Enzimáticos/farmacología; Epigénesis Genética/efectos de los fármacos; Células Epiteliales/efectos de los fármacos; Células Epiteliales/metabolismo; Interacciones Huésped-Patógeno; Humanos; Gripe Humana/metabolismo; Interferón beta/genética; Interferón beta/metabolismo; Interferones/genética; Interferones/metabolismo; Interleucinas/genética; Interleucinas/metabolismo; Cultivo Primario de Células; ARN Mensajero/genética; ARN Mensajero/metabolismo; Receptores Inmunológicos; Fumar/efectos adversos; Fumar/metabolismo; Factores de Tiempo; Receptor Toll-Like 3/genética; Receptor Toll-Like 3/metabolismo

Palabras clave

COPD; HBEC; Human; Influenza; Innate immunity; Interferon; Lung; RIG-I; TLR3

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Bronquios / Fumar / Metilación de ADN / Epigénesis Genética / Células Epiteliales / Gripe Humana / Subtipo H1N1 del Virus de la Influenza A Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Respir Res Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos

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