FLT3 Inhibitors in the Management of Acute Myeloid Leukemia.
Anticancer Agents Med Chem
; 17(8): 1028-1032, 2017.
Article
en En
| MEDLINE
| ID: mdl-27748173
ABSTRACT
In recent years there has been a great improvement in molecular characterization of acute myeloid leukemia (AML) allowing the stratification of patients in different rate of risk. Patients with FLT3 mutated AML have poor prognosis because of resistance to induction chemotherapy or early relapse. Several first and second generation molecules, able to inhibit FLT3 signaling have been developed and many single agent or combination studies are ongoing. Of these, quizartinib seems to have the best clinical activity. Unfortunately, resistance to FLT3 inhibitors has been observed and many scientists are currently investigating new strategy to restore sensitivity to FLT3 inhibitors.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Leucemia Mieloide Aguda
/
Inhibidores de Proteínas Quinasas
/
Tirosina Quinasa 3 Similar a fms
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Anticancer Agents Med Chem
Asunto de la revista:
ANTINEOPLASICOS
/
QUIMICA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Italia