Prospective use of whole genome sequencing (WGS) detected a multi-country outbreak of Salmonella Enteritidis.
Epidemiol Infect
; 145(2): 289-298, 2017 01.
Article
en En
| MEDLINE
| ID: mdl-27780484
ABSTRACT
Since April 2015, whole genome sequencing (WGS) has been the routine test for Salmonella identification, surveillance and outbreak investigation at the national reference laboratory in England and Wales. In May 2015, an outbreak of Salmonella Enteritidis cases was detected using WGS data and investigated. UK cases were interviewed to obtain a food history and links between suppliers were mapped to produce a food chain network for chicken eggs. The association between the food chain network and the phylogeny was explored using a network comparison approach. Food and environmental samples were taken from premises linked to cases and tested for Salmonella. Within the outbreak single nucleotide polymorphism defined cluster, 136 cases were identified in the UK and 18 in Spain. One isolate from a food containing chicken eggs was within the outbreak cluster. There was a significant association between the chicken egg food chain of UK cases and phylogeny of outbreak isolates. This is the first published Salmonella outbreak to be prospectively detected using WGS. This outbreak in the UK was linked with contemporaneous cases in Spain by WGS. We conclude that UK and Spanish cases were exposed to a common source of Salmonella-contaminated chicken eggs.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Salmonella enteritidis
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Infecciones por Salmonella
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Brotes de Enfermedades
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Genoma Bacteriano
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Secuenciación de Nucleótidos de Alto Rendimiento
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Enfermedades Transmitidas por los Alimentos
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Aged80
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Animals
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Child
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Child, preschool
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Female
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Humans
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Infant
País/Región como asunto:
Europa
Idioma:
En
Revista:
Epidemiol Infect
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
/
EPIDEMIOLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Reino Unido