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Discovery of potent inhibitors of the lysophospholipase autotaxin.
Shah, Pritom; Cheasty, Anne; Foxton, Caroline; Raynham, Tony; Farooq, Muddasar; Gutierrez, Irene Farre; Lejeune, Aurore; Pritchard, Michelle; Turnbull, Andrew; Pang, Leon; Owen, Paul; Boyd, Susan; Stowell, Alexandra; Jordan, Allan; Hamilton, Niall M; Hitchin, James R; Stockley, Martin; MacDonald, Ellen; Quesada, Mar Jimenez; Trivier, Elisabeth; Skeete, Jana; Ovaa, Huib; Moolenaar, Wouter H; Ryder, Hamish.
Afiliación
  • Shah P; Cancer Research Technology, Discovery Laboratories, Babraham Research Campus, Cambridge CB22 3AT, UK.
  • Cheasty A; Cancer Research Technology, Discovery Laboratories, Babraham Research Campus, Cambridge CB22 3AT, UK.
  • Foxton C; Cancer Research Technology, Discovery Laboratories, Babraham Research Campus, Cambridge CB22 3AT, UK.
  • Raynham T; Cancer Research Technology, Discovery Laboratories, Babraham Research Campus, Cambridge CB22 3AT, UK.
  • Farooq M; Cancer Research Technology, Discovery Laboratories, Babraham Research Campus, Cambridge CB22 3AT, UK.
  • Gutierrez IF; Cancer Research Technology, Discovery Laboratories, Babraham Research Campus, Cambridge CB22 3AT, UK.
  • Lejeune A; Cancer Research Technology, Discovery Laboratories, Babraham Research Campus, Cambridge CB22 3AT, UK.
  • Pritchard M; Cancer Research Technology, Discovery Laboratories, Babraham Research Campus, Cambridge CB22 3AT, UK.
  • Turnbull A; Cancer Research Technology, Discovery Laboratories, Babraham Research Campus, Cambridge CB22 3AT, UK.
  • Pang L; Cancer Research Technology, Discovery Laboratories, Babraham Research Campus, Cambridge CB22 3AT, UK.
  • Owen P; Cancer Research Technology, Discovery Laboratories, Babraham Research Campus, Cambridge CB22 3AT, UK.
  • Boyd S; Cancer Research Technology, Discovery Laboratories, Babraham Research Campus, Cambridge CB22 3AT, UK.
  • Stowell A; Drug Discovery Unit, Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
  • Jordan A; Drug Discovery Unit, Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
  • Hamilton NM; Drug Discovery Unit, Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
  • Hitchin JR; Drug Discovery Unit, Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
  • Stockley M; Cancer Research Technology, Discovery Laboratories, Babraham Research Campus, Cambridge CB22 3AT, UK.
  • MacDonald E; Cancer Research Technology, Discovery Laboratories, Babraham Research Campus, Cambridge CB22 3AT, UK.
  • Quesada MJ; Cancer Research Technology, Discovery Laboratories, Babraham Research Campus, Cambridge CB22 3AT, UK.
  • Trivier E; Cancer Research Technology, Discovery Laboratories, Babraham Research Campus, Cambridge CB22 3AT, UK.
  • Skeete J; Cancer Research Technology, Discovery Laboratories, Babraham Research Campus, Cambridge CB22 3AT, UK.
  • Ovaa H; Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
  • Moolenaar WH; Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
  • Ryder H; Cancer Research Technology, Discovery Laboratories, Babraham Research Campus, Cambridge CB22 3AT, UK.
Bioorg Med Chem Lett ; 26(22): 5403-5410, 2016 11 15.
Article en En | MEDLINE | ID: mdl-27780639
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Lisofosfolípidos / Hidrolasas Diéster Fosfóricas / Inhibidores Enzimáticos / Lisofosfolipasa Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Lisofosfolípidos / Hidrolasas Diéster Fosfóricas / Inhibidores Enzimáticos / Lisofosfolipasa Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido