Heat Shock Protein 90 Facilitates Latent HIV Reactivation through Maintaining the Function of Positive Transcriptional Elongation Factor b (p-TEFb) under Proteasome Inhibition.

Pan, Xiao-Yan; Zhao, Wei; Wang, Chun-Yan; Lin, Jian; Zeng, Xiao-Yun; Ren, Ru-Xia; Wang, Keng; Xun, Tian-Rong; Shai, Yechiel; Liu, Shu-Wen

Pan, Xiao-Yan; Zhao, Wei; Wang, Chun-Yan; Lin, Jian; Zeng, Xiao-Yun; Ren, Ru-Xia; Wang, Keng; Xun, Tian-Rong; Shai, Yechiel; Liu, Shu-Wen.

Afiliación

Pan XY; From the Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 510515 Guangzhou, China.
Zhao W; From the Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 510515 Guangzhou, China.
Wang CY; the Department of Clinical Laboratory, Nanfang Hospital, Southern Medical University, 510515 Guangzhou, China.
Lin J; From the Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 510515 Guangzhou, China.
Zeng XY; From the Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 510515 Guangzhou, China.
Ren RX; From the Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 510515 Guangzhou, China.
Wang K; From the Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 510515 Guangzhou, China.
Xun TR; From the Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 510515 Guangzhou, China.
Shai Y; the Department of Biochemistry, Weizmann Science Institute, Rehovot 76100, Israel, and Yechiel.Shai@weizmann.ac.il.
Liu SW; From the Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 510515 Guangzhou, China, liusw@smu.edu.cn.

J Biol Chem ; 291(50): 26177-26187, 2016 Dec 09.

Article en En | MEDLINE | ID: mdl-27799305

Asunto(s)

Linfocitos T CD4-Positivos/metabolismo; Quinasa 9 Dependiente de la Ciclina/metabolismo; VIH-1/fisiología; Proteínas HSP90 de Choque Térmico/metabolismo; Complejo de la Endopetidasa Proteasomal/metabolismo; Inhibidores de Proteasoma/farmacología; Activación Viral/efectos de los fármacos; Latencia del Virus/efectos de los fármacos; Linfocitos T CD4-Positivos/virología; Quinasa 9 Dependiente de la Ciclina/genética; Proteínas de Unión al ADN/genética; Proteínas de Unión al ADN/metabolismo; Femenino; Infecciones por VIH/tratamiento farmacológico; Infecciones por VIH/genética; Infecciones por VIH/metabolismo; Proteínas HSP90 de Choque Térmico/genética; Factores de Transcripción del Choque Térmico; Humanos; Masculino; Complejo de la Endopetidasa Proteasomal/genética; Elongación de la Transcripción Genética/efectos de los fármacos; Factores de Transcripción/genética; Factores de Transcripción/metabolismo; Activación Viral/fisiología; Latencia del Virus/fisiología

Palabras clave

Heat shock factor protein 1 (HSF1); cyclin-dependent kinase (CDK); heat shock protein 90 (Hsp90); human immunodeficiency virus (HIV); latency reversing agent; p-TEFb; proteasome

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Activación Viral / Linfocitos T CD4-Positivos / VIH-1 / Latencia del Virus / Proteínas HSP90 de Choque Térmico / Quinasa 9 Dependiente de la Ciclina / Complejo de la Endopetidasa Proteasomal / Inhibidores de Proteasoma Límite: Female / Humans / Male Idioma: En Revista: J Biol Chem Año: 2016 Tipo del documento: Article País de afiliación: China

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