Successful low-dose radiotherapy treatment for Kasabach-Merritt syndrome.
Pediatr Int
; 58(10): 1084-1086, 2016 Oct.
Article
en En
| MEDLINE
| ID: mdl-27804244
ABSTRACT
Kasabach-Merritt syndrome (KMS) is characterized by hemangioma associated with life-threatening thrombocytopenia, and is a consumptive coagulopathy. Although treatments available include corticosteroids, α-interferon, vincristine, and surgery, response may be unsatisfactory, and the mortality rate remains at approximately 30%. Although radiotherapy has been used effectively for KMS, it may cause growth retardation and secondary malignancy. We report a case of KMS in which hemangioma of the left thigh was successfully treated with low-dose radiotherapy (6 Gy in six fractions, weekly) after failure of corticosteroid therapy. No significant late effects due to the radiotherapy were noted at 5 year follow up. Thus, low-dose radiotherapy remains an important treatment method for KMS when patients fail to respond to other treatments.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Radioterapia de Intensidad Modulada
/
Síndrome de Kasabach-Merritt
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
Pediatr Int
Asunto de la revista:
PEDIATRIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Japón