In Vivo Comparison of Tau Radioligands <sup>18</sup>F-THK-5351 and <sup>18</sup>F-THK-5317.

Betthauser, Tobey J; Lao, Patrick J; Murali, Dhanabalan; Barnhart, Todd E; Furumoto, Shozo; Okamura, Nobuyuki; Stone, Charles K; Johnson, Sterling C; Christian, Bradley T

In Vivo Comparison of Tau Radioligands ¹⁸F-THK-5351 and ¹⁸F-THK-5317.

Betthauser, Tobey J; Lao, Patrick J; Murali, Dhanabalan; Barnhart, Todd E; Furumoto, Shozo; Okamura, Nobuyuki; Stone, Charles K; Johnson, Sterling C; Christian, Bradley T.

Afiliación

Betthauser TJ; Department of Medical Physics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin tbetthauser@wisc.edu.
Lao PJ; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Murali D; Department of Medical Physics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Barnhart TE; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Furumoto S; Department of Medical Physics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Okamura N; Department of Medical Physics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Stone CK; Division of Radiopharmaceutical Neuroimaging, Tohoku University, Sendai, Japan.
Johnson SC; Division of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Christian BT; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.

J Nucl Med ; 58(6): 996-1002, 2017 06.

Article en En | MEDLINE | ID: mdl-27856627

Asunto(s)

Enfermedad de Alzheimer/metabolismo; Aminopiridinas/farmacocinética; Compuestos de Anilina/farmacocinética; Encéfalo/metabolismo; Imagen Molecular/métodos; Tomografía de Emisión de Positrones/métodos; Quinolinas/farmacocinética; Proteínas tau/metabolismo; Anciano; Anciano de 80 o más Años; Enfermedad de Alzheimer/diagnóstico por imagen; Biomarcadores/metabolismo; Encéfalo/diagnóstico por imagen; Femenino; Humanos; Marcaje Isotópico/métodos; Masculino; Tasa de Depuración Metabólica; Persona de Mediana Edad; Unión Proteica; Radiofármacos/farmacocinética; Reproducibilidad de los Resultados; Sensibilidad y Especificidad; Distribución Tisular

Palabras clave

Alzheimer's disease; THK; positron emission tomography; quantitation; tau

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Quinolinas / Encéfalo / Proteínas tau / Tomografía de Emisión de Positrones / Imagen Molecular / Enfermedad de Alzheimer / Aminopiridinas / Compuestos de Anilina Tipo de estudio: Diagnostic_studies / Evaluation_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Nucl Med Año: 2017 Tipo del documento: Article

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