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The treatment of bacterial vaginosis in pregnancy with clindamycin to reduce the risk of infection-related preterm birth: a response to the Danish Society of Obstetrics and Gynecology guideline group's clinical recommendations.
Lamont, Ronald F; Keelan, Jeffrey A; Larsson, Per G; Jørgensen, Jan S.
Afiliación
  • Lamont RF; Division of Surgery, University College London, Northwick Park Institute for Medical Research Campus, London, UK.
  • Keelan JA; Department of Gynecology and Obstetrics, Odense University Hospital, Research Unit of Gynecology and Obstetrics, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
  • Larsson PG; School of Women's and Infants' Health, The University of Western Australia, Perth, WA, Australia.
  • Jørgensen JS; Department of Obstetrics and Gynecology, Skaraborg Hospital, University of Linköping, Skövde, Sweden.
Acta Obstet Gynecol Scand ; 96(2): 139-143, 2017 Feb.
Article en En | MEDLINE | ID: mdl-27874978
Preterm birth is the major cause of perinatal mortality and morbidity worldwide. Infection/inflammation is responsible for a significant percentage of preterm birth, particularly at early gestations. A recent clinical recommendation by a guidelines group of the Danish Society of Obstetrics and Gynecology advised against the use of clindamycin for the treatment of bacterial vaginosis in pregnancy to reduce the risk of spontaneous preterm birth based on lack of evidence of efficacy. We believe that the evidence for the use of clindamycin for this indication is robust and that this recommendation was reached erroneously on the basis of flawed inclusion criteria: the inclusion of an unpublished study with poorly diagnosed bacterial vaginosis and the exclusion of an important pivotal study on the use of clindamycin in early pregnancy for the prevention of preterm birth. Had these errors been corrected, the conclusions would have been different.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Complicaciones Infecciosas del Embarazo / Clindamicina / Vaginosis Bacteriana / Guías de Práctica Clínica como Asunto / Nacimiento Prematuro / Antibacterianos Tipo de estudio: Etiology_studies / Guideline / Risk_factors_studies Límite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: Acta Obstet Gynecol Scand Año: 2017 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Complicaciones Infecciosas del Embarazo / Clindamicina / Vaginosis Bacteriana / Guías de Práctica Clínica como Asunto / Nacimiento Prematuro / Antibacterianos Tipo de estudio: Etiology_studies / Guideline / Risk_factors_studies Límite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: Acta Obstet Gynecol Scand Año: 2017 Tipo del documento: Article