Tracheal cartilage growth by intratracheal injection of basic fibroblast growth factor.
J Pediatr Surg
; 52(2): 235-238, 2017 Feb.
Article
en En
| MEDLINE
| ID: mdl-27887682
ABSTRACT
BACKGROUND/PURPOSE:
We have previously shown that intratracheal injection of slowly released (in gelatin) basic fibroblast growth factor (bFGF) significantly enlarged the tracheal lumen by a slight margin. This study aimed to investigate differences in tracheal cartilage growth by the intratracheal injection of bFGF doses in a rabbit model.METHODS:
Water (group 1; n=7; control) or 100µg (group 2; n=8) or 200µg (group 3; n=8) of bFGF dissolved in water was injected into the posterior wall of the cervical trachea of New Zealand white rabbits using a tracheoscope. All animals were sacrificed four weeks later.RESULTS:
The mean circumferences of cervical tracheas for groups 1, 2, and 3 were 18.8±0.83, 21.1±2.0, and 22.1±1.3mm, respectively. A significant difference was found between groups 1 and 2 (P=0.034) and groups 1 and 3 (P=0.004). The mean luminal areas of cervical tracheas for groups 1, 2, and 3 were 27.0±2.1, 32.2±4.8, and 36.3±4.6mm2, respectively. A significant difference was found between groups 1 and 3 (P=0.001).CONCLUSION:
Intratracheal injection of bFGF in the dose range used significantly promoted the growth of tracheal cartilage in a rabbit model. LEVELS OF EVIDENCE Level II at treatment study (animal experiment).Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Tráquea
/
Cartílago
/
Factores de Crecimiento de Fibroblastos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Pediatr Surg
Año:
2017
Tipo del documento:
Article