A method for evaluating the performance of computer-aided detection of pulmonary nodules in lung cancer CT screening: detection limit for nodule size and density.
Br J Radiol
; 90(1070): 20160313, 2017 Feb.
Article
en En
| MEDLINE
| ID: mdl-27897029
ABSTRACT
OBJECTIVE:
We propose the application of virtual nodules to evaluate the performance of computer-aided detection (CAD) of lung nodules in cancer screening using low-dose CT.METHODS:
The virtual nodules were generated based on the spatial resolution measured for a CT system used in an institution providing cancer screening and were fused into clinical lung images obtained at that institution, allowing site specificity. First, we validated virtual nodules as an alternative to artificial nodules inserted into a phantom. In addition, we compared the results of CAD analysis between the real nodules (n = 6) and the corresponding virtual nodules. Subsequently, virtual nodules of various sizes and contrasts between nodule density and background density (ΔCT) were inserted into clinical images (n = 10) and submitted for CAD analysis.RESULTS:
In the validation study, 46 of 48 virtual nodules had the same CAD results as artificial nodules (kappa coefficient = 0.913). Real nodules and the corresponding virtual nodules showed the same CAD results. The detection limits of the tested CAD system were determined in terms of size and density of peripheral lung nodules; we demonstrated that a nodule with a 5-mm diameter was detected when the nodule had a ΔCT > 220 HU.CONCLUSION:
Virtual nodules are effective in evaluating CAD performance using site-specific scan/reconstruction conditions. Advances in knowledge Virtual nodules can be an effective means of evaluating site-specific CAD performance. The methodology for guiding the detection limit for nodule size/density might be a useful evaluation strategy.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Procesamiento de Imagen Asistido por Computador
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Tomografía Computarizada por Rayos X
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Nódulo Pulmonar Solitario
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Nódulos Pulmonares Múltiples
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Límite de Detección
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Neoplasias Pulmonares
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Límite:
Humans
Idioma:
En
Revista:
Br J Radiol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Japón