[The pharmacokinetics of SC1001-sodium and SC1001-aminum in human body].

ABSTRACT

The pharmacokinetics of SC1001-Sodium and SC1001-Aminum in the human body was studied. After 200 mg SC1001-Sodium or SC1001-Aminum by oral administration, plasma concentration-time data were fitted to curves by means of the nonlinear least-square method, employing the program we ourselves compiled. With F-test, comparing gamma 2(1) -value and AIC-value, the linear one compartment open model was available. The mean pharmacokinetic parameters fitted one by one were as follows with the first value given belonging to SC1001-Sodium and the second to SC1001-Aminum Ka 0.7248 and 0.5102 h-1; Ke 0.0597 and 0.1149 h-1; T1/2, a 1.1437 and 1.8999 h; T1/2, e 15.7428 and 6.1497 h; AUC 600.15 and 28.61 micrograms.h/ml; Tm 4.4798 and 4.3728h.