Plasmodium knowlesi: a relevant, versatile experimental malaria model.
Parasitology
; 145(1): 56-70, 2018 01.
Article
en En
| MEDLINE
| ID: mdl-27938428
ABSTRACT
The primate malaria Plasmodium knowlesi has a long-standing history as an experimental malaria model. Studies using this model parasite in combination with its various natural and experimental non-human primate hosts have led to important advances in vaccine development and in our understanding of malaria invasion, immunology and parasite-host interactions. The adaptation to long-term in vitro continuous blood stage culture in rhesus monkey, Macaca fascicularis and human red blood cells, as well as the development of various transfection methodologies has resulted in a highly versatile experimental malaria model, further increasing the potential of what was already a very powerful model. The growing evidence that P. knowlesi is an important human zoonosis in South-East Asia has added relevance to former and future studies of this parasite species.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Plasmodium knowlesi
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Haplorrinos
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Modelos Animales de Enfermedad
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Interacciones Huésped-Parásitos
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Malaria
Tipo de estudio:
Prognostic_studies
Límite:
Animals
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Humans
Idioma:
En
Revista:
Parasitology
Año:
2018
Tipo del documento:
Article
País de afiliación:
Países Bajos