MicroRNA-17 is downregulated in esophageal adenocarcinoma cancer stem-like cells and promotes a radioresistant phenotype.

Lynam-Lennon, Niamh; Heavey, Susan; Sommerville, Gary; Bibby, Becky A S; Ffrench, Brendan; Quinn, Jennifer; Gasch, Claudia; O'Leary, John J; Gallagher, Michael F; Reynolds, John V; Maher, Stephen G

Lynam-Lennon, Niamh; Heavey, Susan; Sommerville, Gary; Bibby, Becky A S; Ffrench, Brendan; Quinn, Jennifer; Gasch, Claudia; O'Leary, John J; Gallagher, Michael F; Reynolds, John V; Maher, Stephen G.

Afiliación

Lynam-Lennon N; Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.
Heavey S; Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.
Sommerville G; Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.
Bibby BA; Cancer Biology and Therapeutics Lab, School of Life Sciences, University of Hull, Hull, United Kingdom.
Ffrench B; Department of Histopathology, Trinity College Dublin, Sir Patrick Dun Laboratory, Central Pathology Laboratory, St James's Hospital, Dublin 8, Ireland.
Quinn J; Molecular Pathology Laboratory, Coombe Women and Infant's University Hospital, Dublin 8, Ireland.
Gasch C; Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.
O'Leary JJ; Department of Histopathology, Trinity College Dublin, Sir Patrick Dun Laboratory, Central Pathology Laboratory, St James's Hospital, Dublin 8, Ireland.
Gallagher MF; Molecular Pathology Laboratory, Coombe Women and Infant's University Hospital, Dublin 8, Ireland.
Reynolds JV; Department of Histopathology, Trinity College Dublin, Sir Patrick Dun Laboratory, Central Pathology Laboratory, St James's Hospital, Dublin 8, Ireland.
Maher SG; Molecular Pathology Laboratory, Coombe Women and Infant's University Hospital, Dublin 8, Ireland.

Oncotarget ; 8(7): 11400-11413, 2017 Feb 14.

Article en En | MEDLINE | ID: mdl-28002789

Asunto(s)

Adenocarcinoma/genética; Adenocarcinoma/patología; Neoplasias Esofágicas/genética; Neoplasias Esofágicas/patología; MicroARNs/biosíntesis; Células Madre Neoplásicas/patología; Tolerancia a Radiación/genética; Adenocarcinoma/metabolismo; Animales; Línea Celular Tumoral; Separación Celular; Regulación hacia Abajo; Neoplasias Esofágicas/metabolismo; Femenino; Perfilación de la Expresión Génica; Regulación Neoplásica de la Expresión Génica/genética; Xenoinjertos; Humanos; Ratones; Ratones Endogámicos NOD; Ratones SCID; MicroARNs/genética; Células Madre Neoplásicas/metabolismo; Reacción en Cadena de la Polimerasa; Transcriptoma

Palabras clave

cancer stem-like cells; esophageal adenocarcinoma; microRNA; predictive biomarker; radioresistance

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Tolerancia a Radiación / Células Madre Neoplásicas / Neoplasias Esofágicas / Adenocarcinoma / MicroARNs Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Oncotarget Año: 2017 Tipo del documento: Article País de afiliación: Irlanda

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