Organocatalytic Insertion of Isatins into Aryl Difluoronitromethyl Ketones.
J Org Chem
; 82(2): 1273-1278, 2017 01 20.
Article
en En
| MEDLINE
| ID: mdl-28032765
ABSTRACT
An organocatalytic method that achieves insertion of isatins into aryl difluoronitromethyl ketones under mild conditions is described. The reaction occurs in the presence of 20 mol % of DBU and with 100% atom economy. A series of isatin derived difluoronitromethyl substituted tertiary alcohol benzoates and naphthoates were prepared in 81-99% yield. The general synthetic usefulness of these 3-hydroxyoxindole derivatives is demonstrated with the selective reduction to fluorooximes.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Química Orgánica
/
Isatina
/
Cetonas
Idioma:
En
Revista:
J Org Chem
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos