Branched Macromolecular Architectures for Degradable, Multifunctional Phosphorus-Based Polymers.
Macromol Rapid Commun
; 38(4)2017 Feb.
Article
en En
| MEDLINE
| ID: mdl-28044384
ABSTRACT
This feature article briefly highlights some of the recent advances in polymers in which phosphorus is an integral part of the backbone, with a focus on the preparation of functional, highly branched, soluble polymers. A comparison is made between the related families of materials polyphosphazenes, phosphazene/phosphorus-based dendrimers and polyphosphoesters. The work described herein shows this to be a rich and burgeoning field, rapidly catching up with organic chemistry in terms of the macromolecular synthetic control and variety of available macromolecular architectures, whilst offering unique property combinations not available with carbon backbones, such as tunable degradation rates, high multi-valency and facile post-polymerization functionalization. As an example of their use in advanced applications, we highlight some investigations into their use as water-soluble drug carriers, whereby in particular the degradability in combination with multivalent nature has made them useful materials, as underlined by some of the recent studies in this area.
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Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fósforo
/
Polímeros
/
Sustancias Macromoleculares
Idioma:
En
Revista:
Macromol Rapid Commun
Año:
2017
Tipo del documento:
Article
País de afiliación:
Austria