Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA-Encoded Chemical Library.

Cuozzo, John W; Centrella, Paolo A; Gikunju, Diana; Habeshian, Sevan; Hupp, Christopher D; Keefe, Anthony D; Sigel, Eric A; Soutter, Holly H; Thomson, Heather A; Zhang, Ying; Clark, Matthew A

Cuozzo, John W; Centrella, Paolo A; Gikunju, Diana; Habeshian, Sevan; Hupp, Christopher D; Keefe, Anthony D; Sigel, Eric A; Soutter, Holly H; Thomson, Heather A; Zhang, Ying; Clark, Matthew A.

Afiliación

Cuozzo JW; X-Chem Pharmaceuticals, 100 Beaver Street, Waltham, MA, 02453, USA.
Centrella PA; X-Chem Pharmaceuticals, 100 Beaver Street, Waltham, MA, 02453, USA.
Gikunju D; X-Chem Pharmaceuticals, 100 Beaver Street, Waltham, MA, 02453, USA.
Habeshian S; X-Chem Pharmaceuticals, 100 Beaver Street, Waltham, MA, 02453, USA.
Hupp CD; X-Chem Pharmaceuticals, 100 Beaver Street, Waltham, MA, 02453, USA.
Keefe AD; X-Chem Pharmaceuticals, 100 Beaver Street, Waltham, MA, 02453, USA.
Sigel EA; X-Chem Pharmaceuticals, 100 Beaver Street, Waltham, MA, 02453, USA.
Soutter HH; X-Chem Pharmaceuticals, 100 Beaver Street, Waltham, MA, 02453, USA.
Thomson HA; X-Chem Pharmaceuticals, 100 Beaver Street, Waltham, MA, 02453, USA.
Zhang Y; X-Chem Pharmaceuticals, 100 Beaver Street, Waltham, MA, 02453, USA.
Clark MA; X-Chem Pharmaceuticals, 100 Beaver Street, Waltham, MA, 02453, USA.

Chembiochem ; 18(9): 864-871, 2017 05 04.

Article en En | MEDLINE | ID: mdl-28056160

Asunto(s)

ADN/química; Inhibidores de Proteínas Quinasas/química; Proteínas Tirosina Quinasas/antagonistas & inhibidores; Bibliotecas de Moléculas Pequeñas/química; Agammaglobulinemia Tirosina Quinasa; Sitios de Unión; Línea Celular; Citocromo P-450 CYP3A/química; Citocromo P-450 CYP3A/metabolismo; ADN/metabolismo; Humanos; Cinética; Simulación del Acoplamiento Molecular; Unión Proteica; Inhibidores de Proteínas Quinasas/metabolismo; Estructura Terciaria de Proteína; Proteínas Tirosina Quinasas/genética; Proteínas Tirosina Quinasas/metabolismo; Bibliotecas de Moléculas Pequeñas/metabolismo

Palabras clave

Bruton's tyrosine kinase; DNA-encoded library; X-ray crystallography; kinase inhibitors; small molecules

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas Tirosina Quinasas / ADN / Inhibidores de Proteínas Quinasas / Bibliotecas de Moléculas Pequeñas Límite: Humans Idioma: En Revista: Chembiochem Asunto de la revista: BIOQUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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