The Influence of the Microbiome on Allergic Sensitization to Food.
J Immunol
; 198(2): 581-589, 2017 01 15.
Article
en En
| MEDLINE
| ID: mdl-28069753
ABSTRACT
The alarming increase in the incidence and severity of food allergies has coincided with lifestyle changes in Western societies, such as dietary modifications and increased antibiotic use. These demographic shifts have profoundly altered the coevolved relationship between host and microbiota, depleting bacterial populations critical for the maintenance of mucosal homeostasis. There is increasing evidence that the dysbiosis associated with sensitization to food fails to stimulate protective tolerogenic pathways, leading to the development of the type 2 immune responses that characterize allergic disease. Defining the role of beneficial allergy-protective members of the microbiota in the regulation of tolerance to food has exciting potential for new interventions to treat dietary allergies by modulation of the microbiota.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Inmunidad Mucosa
/
Disbiosis
/
Microbioma Gastrointestinal
/
Hipersensibilidad a los Alimentos
Límite:
Humans
Idioma:
En
Revista:
J Immunol
Año:
2017
Tipo del documento:
Article