A quality by design (QbD) study on enoxaparin sodium loaded polymeric microspheres for colon-specific delivery.

Hales, Dana; Vlase, Laurian; Porav, Sebastian Alin; Bodoki, Andreea; Barbu-Tudoran, Lucian; Achim, Marcela; TomuÈa, Ioan

Hales, Dana; Vlase, Laurian; Porav, Sebastian Alin; Bodoki, Andreea; Barbu-Tudoran, Lucian; Achim, Marcela; TomuÈa, Ioan.

Afiliación

Hales D; Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy "Iuliu Hatieganu", 41 Victor BabeÈ street, 400012 Cluj-Napoca, Romania. Electronic address: dudas.dana@umfcluj.ro.
Vlase L; Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy "Iuliu Hatieganu", 41 Victor BabeÈ street, 400012 Cluj-Napoca, Romania. Electronic address: laurian.vlase@umfcluj.ro.
Porav SA; Electron Microscopy Center, BabeÈ-Bolyai University, 5-7 Clinicilor street, 400006 Cluj-Napoca, Romania. Electronic address: porav_sebastian@yahoo.com.
Bodoki A; Department of General and Inorganic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy "Iuliu HaÈieganu", 12 Ion Creanga street, 400010 Cluj-Napoca, Romania. Electronic address: abota@umfcluj.ro.
Barbu-Tudoran L; Electron Microscopy Center, BabeÈ-Bolyai University, 5-7 Clinicilor street, 400006 Cluj-Napoca, Romania. Electronic address: lbarbu@hasdeu.ubbcluj.ro.
Achim M; Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy "Iuliu Hatieganu", 41 Victor BabeÈ street, 400012 Cluj-Napoca, Romania. Electronic address: machim@umfcluj.ro.
TomuÈa I; Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy "Iuliu Hatieganu", 41 Victor BabeÈ street, 400012 Cluj-Napoca, Romania. Electronic address: tomutaioan@umfcluj.ro.

Eur J Pharm Sci ; 100: 249-261, 2017 Mar 30.

Article en En | MEDLINE | ID: mdl-28088371

Asunto(s)

Anticoagulantes/química; Enoxaparina/química; Microesferas; Colon; Sistemas de Liberación de Medicamentos; Diseño de Fármacos; Liberación de Fármacos; Tamaño de la Partícula; Ácidos Polimetacrílicos/química; Alcohol Polivinílico/química; Cloruro de Sodio/química

Palabras clave

Colon-specific delivery; Enoxaparin sodium (PubChem CID: 772); Eudragit® FS; Eudragit® FS (PubChem CID: 161546); Eudragit® RS; Eudragit® RS (PubChem CID: 104931); Microspheres; Poly(vinyl alcohol) (PubChem CID: 11199); Quality by design; Sodium chloride; Sodium chloride (PubChem CID: 5234)

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enoxaparina / Microesferas / Anticoagulantes Idioma: En Revista: Eur J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2017 Tipo del documento: Article

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