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Application of a systems pharmacology model for translational prediction of hERG-mediated QTc prolongation.
Gotta, Verena; Yu, Zhiyi; Cools, Frank; van Ammel, Karel; Gallacher, David J; Visser, Sandra A G; Sannajust, Frederick; Morissette, Pierre; Danhof, Meindert; van der Graaf, Piet H.
Afiliación
  • Gotta V; Systems Pharmacology Leiden Academic Centre for Drug Research (LACDR) Leiden University Leiden The Netherlands; Pediatric Pharmacology and Pharmacometrics University of Basel Children's Hospital (UKBB) Basel Switzerland.
  • Yu Z; Division of Medicinal Chemistry Leiden Academic Centre for Drug Research (LACDR) Leiden University Leiden The Netherlands.
  • Cools F; Global Safety Pharmacology Janssen Research & Development Janssen Pharmaceutica NV Beerse Belgium.
  • van Ammel K; Global Safety Pharmacology Janssen Research & Development Janssen Pharmaceutica NV Beerse Belgium.
  • Gallacher DJ; Global Safety Pharmacology Janssen Research & Development Janssen Pharmaceutica NV Beerse Belgium.
  • Visser SA; Quantitative Pharmacology and Pharmacometrics/Merck Research Laboratories Merck & Co., Inc. Upper Gwynedd Pennsylvania.
  • Sannajust F; SALAR-Safety and Exploratory Pharmacology Department/Merck Research Laboratories Merck & Co., Inc. West Point Pennsylvania.
  • Morissette P; SALAR-Safety and Exploratory Pharmacology Department/Merck Research Laboratories Merck & Co., Inc. West Point Pennsylvania.
  • Danhof M; Systems Pharmacology Leiden Academic Centre for Drug Research (LACDR) Leiden University Leiden The Netherlands.
  • van der Graaf PH; Systems Pharmacology Leiden Academic Centre for Drug Research (LACDR) Leiden University Leiden The Netherlands; Certara Quantitative Systems Pharmacology Canterbury United Kingdom.
Pharmacol Res Perspect ; 4(6): e00270, 2016 12.
Article en En | MEDLINE | ID: mdl-28097003
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Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Pharmacol Res Perspect Año: 2016 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Pharmacol Res Perspect Año: 2016 Tipo del documento: Article