RNA Nanoparticle-Based Targeted Therapy for Glioblastoma through Inhibition of Oncogenic miR-21.

Lee, Tae Jin; Yoo, Ji Young; Shu, Dan; Li, Hui; Zhang, Jianying; Yu, Jun-Ge; Jaime-Ramirez, Alena Cristina; Acunzo, Mario; Romano, Giulia; Cui, Ri; Sun, Hui-Lung; Luo, Zhenghua; Old, Matthew; Kaur, Balveen; Guo, Peixuan; Croce, Carlo M

Lee, Tae Jin; Yoo, Ji Young; Shu, Dan; Li, Hui; Zhang, Jianying; Yu, Jun-Ge; Jaime-Ramirez, Alena Cristina; Acunzo, Mario; Romano, Giulia; Cui, Ri; Sun, Hui-Lung; Luo, Zhenghua; Old, Matthew; Kaur, Balveen; Guo, Peixuan; Croce, Carlo M.

Afiliación

Lee TJ; Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Yoo JY; Department of Neurological Surgery, College of Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Shu D; Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Li H; Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Zhang J; Department of Biomedical Informatics, Center for Biostatistics, Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, OH 43210, USA.
Yu JG; Department of Otolaryngology, Head & Neck Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA.
Jaime-Ramirez AC; Department of Neurological Surgery, College of Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Acunzo M; Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Romano G; Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Cui R; Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Sun HL; Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Luo Z; Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Old M; Department of Otolaryngology, Head & Neck Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA.
Kaur B; Department of Neurological Surgery, College of Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Guo P; Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210, USA. Ele
Croce CM; Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA. Electronic address: carlo.croce@osumc.edu.

Mol Ther ; 25(7): 1544-1555, 2017 07 05.

Article en En | MEDLINE | ID: mdl-28109960

Asunto(s)

Antagomirs/farmacología; Neoplasias Encefálicas/terapia; Regulación Neoplásica de la Expresión Génica; Glioblastoma/terapia; MicroARNs/antagonistas & inhibidores; Nanopartículas/administración & dosificación; Animales; Antagomirs/química; Antagomirs/metabolismo; Proteínas Reguladoras de la Apoptosis/genética; Proteínas Reguladoras de la Apoptosis/metabolismo; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/mortalidad; Neoplasias Encefálicas/patología; Línea Celular Tumoral; Portadores de Fármacos; Femenino; Receptores de Folato Anclados a GPI/genética; Receptores de Folato Anclados a GPI/metabolismo; Ácido Fólico/química; Ácido Fólico/metabolismo; Glioblastoma/genética; Glioblastoma/mortalidad; Glioblastoma/patología; Humanos; Ratones; Ratones Desnudos; MicroARNs/genética; MicroARNs/metabolismo; Nanopartículas/química; Oligonucleótidos/química; Oligonucleótidos/metabolismo; Fosfohidrolasa PTEN/genética; Fosfohidrolasa PTEN/metabolismo; Proteínas de Unión al ARN/genética; Proteínas de Unión al ARN/metabolismo; Análisis de Supervivencia; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

3WJ; RNA nanoparticle; apoptosis; glioblastoma; microRNA

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Regulación Neoplásica de la Expresión Génica / Glioblastoma / MicroARNs / Nanopartículas / Antagomirs Tipo de estudio: Prognostic_studies Idioma: En Revista: Mol Ther Asunto de la revista: BIOLOGIA MOLECULAR / TERAPEUTICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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