Gelsolin Inhibits the Inflammatory Process Induced by LPS.
Cell Physiol Biochem
; 41(1): 205-212, 2017.
Article
en En
| MEDLINE
| ID: mdl-28135711
ABSTRACT
BACKGROUND/AIMS:
Endotoxemia is a life-threatening situation that signifies a key challenge in the field of intensive care medicine. Proinflammatory mediators produced by macrophages play a key role in endotoxemia. Gelsolin (GSN) is involved in the process of inflammation.METHODS:
IL-6 and TNF-α in the supernatant were measured with an ELISA kit. NO production was assessed by measurement of nitrite concentration with the Griess assay. si-RNA directed against GSN (si-GSN) was transfected by Lipofectamine.RESULTS:
LPS decreased the levels of GSN. Recombinant GSN inhibited the cytokines induced by LPS and rescued mice from LPS-induced death, and si-GSN increased death in the LPS-pretreated mice.CONCLUSION:
GSN exhibited a protective role in endotoxemia.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Lipopolisacáridos
/
Gelsolina
/
Endotoxemia
Límite:
Animals
Idioma:
En
Revista:
Cell Physiol Biochem
Asunto de la revista:
BIOQUIMICA
/
FARMACOLOGIA
Año:
2017
Tipo del documento:
Article