From Genotype to Phenotype: Cytochrome P450 2D6-Mediated Drug Clearance in Humans.

Gao, Jie; Tian, Xin; Zhou, Jun; Cui, Ming-Zhu; Zhang, Hai-Feng; Gao, Na; Wen, Qiang; Qiao, Hai-Ling

Gao, Jie; Tian, Xin; Zhou, Jun; Cui, Ming-Zhu; Zhang, Hai-Feng; Gao, Na; Wen, Qiang; Qiao, Hai-Ling.

Afiliación

Gao J; Institute of Clinical Pharmacology, Zhengzhou University , Zhengzhou, Henan 450052, China.
Tian X; Institute of Clinical Pharmacology, Zhengzhou University , Zhengzhou, Henan 450052, China.
Zhou J; Institute of Clinical Pharmacology, Zhengzhou University , Zhengzhou, Henan 450052, China.
Cui MZ; Institute of Clinical Pharmacology, Zhengzhou University , Zhengzhou, Henan 450052, China.
Zhang HF; Institute of Clinical Pharmacology, Zhengzhou University , Zhengzhou, Henan 450052, China.
Gao N; Institute of Clinical Pharmacology, Zhengzhou University , Zhengzhou, Henan 450052, China.
Wen Q; Institute of Clinical Pharmacology, Zhengzhou University , Zhengzhou, Henan 450052, China.
Qiao HL; Institute of Clinical Pharmacology, Zhengzhou University , Zhengzhou, Henan 450052, China.

Mol Pharm ; 14(3): 649-657, 2017 03 06.

Article en En | MEDLINE | ID: mdl-28211700

Asunto(s)

Citocromo P-450 CYP2D6/genética; Dextrometorfano/metabolismo; Tasa de Depuración Metabólica/genética; Variación Genética/genética; Genotipo; Humanos; Cinética; Fenotipo

Palabras clave

CYP2D6; dextromethorphan; drug clearance; genotype−phenotype relationship; intragenotype individual variation

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Tasa de Depuración Metabólica / Citocromo P-450 CYP2D6 / Dextrometorfano Límite: Humans Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: China

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