"Atypical" atypical parkinsonism: Critical appraisal of a cohort.
Parkinsonism Relat Disord
; 37: 36-42, 2017 04.
Article
en En
| MEDLINE
| ID: mdl-28236526
ABSTRACT
BACKGROUND:
Atypical parkinsonian conditions such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP), corticobasal syndrome (CBS) and Dementia with Lewy bodies (DLB) comprise 10-15% of parkinsonian syndromes. Misdiagnosis with Parkinson disease (PD) and within the entities is common, given the absence of reliable biomarkers. However a correct diagnosis is not only important in clinical practice, but also crucial for any trial attempting to identify biomarkers or new treatments.METHODS:
Consecutive patients, who were referred to our tertiary center with a diagnosis of a particular AP were included and the medical records were reviewed retrospectively. We applied each set of current diagnostic research criteria to the respective cohort to see which features fit in and if there are any additional atypical features "outside" the classic definition.RESULTS:
Sixty-nine patients were recruited between January 2013 and May 2015 clinically presenting with one of the following phenotypes 14 MSA, 24 PSP, 19 CBS and 12 DLB. Up to 49% showed additional "atypical" features and approximately 10% eventually received an alternative diagnosis, in half of whom this being based on genetic testing.CONCLUSIONS:
In a subset of our patients, despite the final diagnosis of an AP being maintained, there were additional "atypical" features. It remains to be seen if these reflect the clinical heterogeneity of APs, or should prompt a search for an alternative diagnosis. The search for biomarkers is more likely to be successful in homogenous groups of "typical" patients, hence the importance of recognizing "atypical" features.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Parálisis Supranuclear Progresiva
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Atrofia de Múltiples Sistemas
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Trastornos Parkinsonianos
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Enfermedad por Cuerpos de Lewy
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Diagnóstico Diferencial
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Parkinsonism Relat Disord
Asunto de la revista:
NEUROLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Reino Unido