Role of the liver X receptors in skin physiology: Putative pharmacological targets in human diseases.
Chem Phys Lipids
; 207(Pt B): 59-68, 2017 10.
Article
en En
| MEDLINE
| ID: mdl-28259649
ABSTRACT
Liver X receptors (LXRs) are members of the nuclear receptor superfamily that have been shown to regulate various physiological functions such as lipid metabolism and cholesterol homeostasis. Concordant reports have elicited the possibility to target them to cure many human diseases including arteriosclerosis, cancer, arthritis, and diabetes. The high relevance of modulating LXR activities to treat numerous skin diseases, mainly those with exacerbated inflammation processes, contrasts with the lack of approved therapeutic use. This review makes an assessment to sum up the findings regarding the physiological roles of LXRs in skin and help progress towards the therapeutic and safe management of their activities. It focuses on the possible pharmacological targeting of LXRs to cure or prevent selected skin diseases.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Artritis Reumatoide
/
Piel
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Diabetes Mellitus
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Aterosclerosis
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Receptores X del Hígado
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Chem Phys Lipids
Año:
2017
Tipo del documento:
Article
País de afiliación:
Francia