Rapid access to 6â³-functionalized α-galactosyl ceramides by using 2-naphthylmethyl ether as the permanent protecting group.
Bioorg Med Chem Lett
; 27(8): 1795-1798, 2017 04 15.
Article
en En
| MEDLINE
| ID: mdl-28274628
ABSTRACT
A versatile strategy for the synthesis of 6â³-functionalized α-GalCers by using NAP ether group for permanent hydroxyl protection was developed, which provide the flexibility necessary for the incorporation of a wide range of functional groups in target molecules including alkyne, azide, thiol that are intolerant to Pd-catalyzed hydrogenolysis as well as other functionalities like carboxylic acid and amine. This strategy is also adaptable to other glycoconjugate synthesis especially those containing clickable tags and unsaturated functionalities.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Adyuvantes Inmunológicos
/
Galactosilceramidas
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2017
Tipo del documento:
Article
País de afiliación:
China