Disability progression markers over 6-12 years in interferon-ß-treated multiple sclerosis patients.
Mult Scler
; 24(3): 322-330, 2018 03.
Article
en En
| MEDLINE
| ID: mdl-28287331
ABSTRACT
OBJECTIVE:
To investigate the association between activity during interferon-beta (IFNß) therapy and disability outcomes in patients with relapsing-remitting multiple sclerosis (RRMS).METHODS:
A longitudinal study based on two previously described cohorts of IFNß-treated RRMS patients was conducted. Patients were classified according to clinical activity after 2 years (clinical cohort) or to clinical and radiological activity after 1 year (magnetic resonance imaging (MRI) cohort). Multivariate Cox models were calculated for early disease activity predicting long-term disability.RESULTS:
A total of 516 patients from two different cohorts were included in the analyses. Persistent clinical disease activity during the first 2 years of therapy predicted severe long-term disability (clinical cohort). In the MRI cohort, modified Rio score and no or minimal evidence of disease activity (NEDA/MEDA) did not identify patients with risk of Expanded Disability Status Scale (EDSS) worsening. However, a Rio score ≥ 2 (hazard ratio (HR) 3.3, 95% confidence interval (CI) 1.7-6.4); ≥3 new T2 lesions (HR 2.9, 95% CI 1.5-5.6); or ≥2 Gd-enhancing lesions (HR 2.1, 95% CI 1.1-4) were able to identify patients with EDSS worsening.CONCLUSION:
Although early activity during IFNß therapy is associated with poor long-term outcomes, minimal degree of activity does not seem to be predictive of EDSS worsening over 6.7-year mean follow-up.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Índice de Severidad de la Enfermedad
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Evaluación de Resultado en la Atención de Salud
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Interferón beta
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Progresión de la Enfermedad
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Esclerosis Múltiple Recurrente-Remitente
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Factores Inmunológicos
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Mult Scler
Asunto de la revista:
NEUROLOGIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
España