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Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors.
Gholamin, Sharareh; Mitra, Siddhartha S; Feroze, Abdullah H; Liu, Jie; Kahn, Suzana A; Zhang, Michael; Esparza, Rogelio; Richard, Chase; Ramaswamy, Vijay; Remke, Marc; Volkmer, Anne K; Willingham, Stephen; Ponnuswami, Anitha; McCarty, Aaron; Lovelace, Patricia; Storm, Theresa A; Schubert, Simone; Hutter, Gregor; Narayanan, Cyndhavi; Chu, Pauline; Raabe, Eric H; Harsh, Griffith; Taylor, Michael D; Monje, Michelle; Cho, Yoon-Jae; Majeti, Ravi; Volkmer, Jens P; Fisher, Paul G; Grant, Gerald; Steinberg, Gary K; Vogel, Hannes; Edwards, Michael; Weissman, Irving L; Cheshier, Samuel H.
Afiliación
  • Gholamin S; Division of Pediatric Neurosurgery, Department of Neurosurgery, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Mitra SS; Institute for Stem Cell Biology and Regenerative Medicine and the Stanford Ludwig Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Feroze AH; Division of Pediatric Neurosurgery, Department of Neurosurgery, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA 94305, USA. smitra@stanford.edu cheshier@stanford.edu.
  • Liu J; Institute for Stem Cell Biology and Regenerative Medicine and the Stanford Ludwig Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Kahn SA; Division of Pediatric Neurosurgery, Department of Neurosurgery, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Zhang M; Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Esparza R; Division of Pediatric Neurosurgery, Department of Neurosurgery, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Richard C; Institute for Stem Cell Biology and Regenerative Medicine and the Stanford Ludwig Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Ramaswamy V; Division of Pediatric Neurosurgery, Department of Neurosurgery, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Remke M; Division of Pediatric Neurosurgery, Department of Neurosurgery, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Volkmer AK; Division of Pediatric Neurosurgery, Department of Neurosurgery, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Willingham S; Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • Ponnuswami A; Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • McCarty A; Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • Lovelace P; Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • Storm TA; Division of Pediatric Neurooncology, German Consortium for Translational Cancer Research, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
  • Schubert S; Institute for Stem Cell Biology and Regenerative Medicine and the Stanford Ludwig Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Hutter G; Department of Gynecology and Obstetrics, University of Düsseldorf, 40225 Düsseldorf, Germany.
  • Narayanan C; Institute for Stem Cell Biology and Regenerative Medicine and the Stanford Ludwig Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Chu P; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Raabe EH; Institute for Stem Cell Biology and Regenerative Medicine and the Stanford Ludwig Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Harsh G; Institute for Stem Cell Biology and Regenerative Medicine and the Stanford Ludwig Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Taylor MD; Institute for Stem Cell Biology and Regenerative Medicine and the Stanford Ludwig Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Monje M; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Cho YJ; Division of Pediatric Neurosurgery, Department of Neurosurgery, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Majeti R; Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Volkmer JP; Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Fisher PG; Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • Grant G; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Steinberg GK; Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • Vogel H; Division of Pediatric Neurosurgery, Department of Neurosurgery, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Edwards M; Institute for Stem Cell Biology and Regenerative Medicine and the Stanford Ludwig Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Weissman IL; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Cheshier SH; Department of Pediatrics and Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97231, USA.
Sci Transl Med ; 9(381)2017 03 15.
Article en En | MEDLINE | ID: mdl-28298418
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fagocitosis / Neoplasias Encefálicas / Receptores Inmunológicos / Antígenos de Diferenciación / Antígeno CD47 / Anticuerpos Límite: Animals / Child / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fagocitosis / Neoplasias Encefálicas / Receptores Inmunológicos / Antígenos de Diferenciación / Antígeno CD47 / Anticuerpos Límite: Animals / Child / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos