Treatment of premenstrual dysphoric disorder with the GABA<sub>A</sub> receptor modulating steroid antagonist Sepranolone (UC1010)-A randomized controlled trial.

Bixo, Marie; Ekberg, Karin; Poromaa, Inger Sundström; Hirschberg, Angelica Lindén; Jonasson, Aino Fianu; Andréen, Lotta; Timby, Erika; Wulff, Marianne; Ehrenborg, Agneta; Bäckström, Torbjörn

Treatment of premenstrual dysphoric disorder with the GABA_A receptor modulating steroid antagonist Sepranolone (UC1010)-A randomized controlled trial.

Bixo, Marie; Ekberg, Karin; Poromaa, Inger Sundström; Hirschberg, Angelica Lindén; Jonasson, Aino Fianu; Andréen, Lotta; Timby, Erika; Wulff, Marianne; Ehrenborg, Agneta; Bäckström, Torbjörn.

Afiliación

Bixo M; Department of Clinical Science, Umeå University, SE-901 85 Umeå, Sweden. Electronic address: marie.bixo@umu.se.
Ekberg K; Asarina Pharma AB, Fogdevreten 2, SE-171 65 Solna, Sweden.
Poromaa IS; Department of Women's and Children's Health, Uppsala University, SE-751 85 Uppsala, Sweden.
Hirschberg AL; Department of Women's and Children's Health, Karolinska Institutet and Department of Obstetrics and Gynecology, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
Jonasson AF; Kvinnoforskningsenheten, Karolinska University Hospital, SE-141 46 Huddinge, Sweden.
Andréen L; Department of Obstetrics and Gynecology, Sundsvall Hospital, SE-851 86 Sundsvall, Sweden.
Timby E; Department of Clinical Science, Umeå University, SE-901 85 Umeå, Sweden.
Wulff M; Slottsstadens Läkarhus Malmö, Fågelbacksgatan 11, SE-217 44 Malmö, Sweden.
Ehrenborg A; Specialistläkarna Kungsbacka (Qvinnolivet), Södra Torggatan 18, SE-434 30 Kungsbacka, Sweden.
Bäckström T; Department of Clinical Science, Umeå University, SE-901 85 Umeå, Sweden.

Psychoneuroendocrinology ; 80: 46-55, 2017 Jun.

Article en En | MEDLINE | ID: mdl-28319848

Asunto(s)

Pregnanolona/farmacología; Pregnanolona/uso terapéutico; Trastorno Disfórico Premenstrual/tratamiento farmacológico; Adulto; Afecto/fisiología; Ira; Ansiedad; Anticonceptivos Orales/farmacología; Depresión; Método Doble Ciego; Femenino; Fase Folicular; Antagonistas de Receptores de GABA-A/farmacología; Humanos; Fase Luteínica/efectos de los fármacos; Ciclo Menstrual; Persona de Mediana Edad; Síndrome Premenstrual; Progesterona/farmacología; Receptores de GABA-A/efectos de los fármacos; Receptores de GABA-A/metabolismo; Inhibidores Selectivos de la Recaptación de Serotonina/farmacología

Palabras clave

Allopregnanolone; GABA; Isoallopregnanolone; Premenstrual dysphoric disorder; Randomized controlled trial

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Pregnanolona / Trastorno Disfórico Premenstrual Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Psychoneuroendocrinology Año: 2017 Tipo del documento: Article

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