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The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures.
Narayan, Ravi S; Fedrigo, Carlos A; Brands, Eelke; Dik, Rogier; Stalpers, Lukas J A; Baumert, Brigitta G; Slotman, Ben J; Westerman, Bart A; Peters, Godefridus J; Sminia, Peter.
Afiliación
  • Narayan RS; Department of Radiation Oncology, VU University Medical Center/Cancer Center Amsterdam, P.O. Box 7057, Amsterdam, 1007, MB, The Netherlands.
  • Fedrigo CA; Department of Radiation Oncology, VU University Medical Center/Cancer Center Amsterdam, P.O. Box 7057, Amsterdam, 1007, MB, The Netherlands.
  • Brands E; Department of Radiation Oncology, VU University Medical Center/Cancer Center Amsterdam, P.O. Box 7057, Amsterdam, 1007, MB, The Netherlands.
  • Dik R; Department of Radiation Oncology, VU University Medical Center/Cancer Center Amsterdam, P.O. Box 7057, Amsterdam, 1007, MB, The Netherlands.
  • Stalpers LJ; Department of Radiation Oncology, Academic Medical Center, Amsterdam, The Netherlands.
  • Baumert BG; Clinical Cooperation Unit Neurooncology, MediClin Robert Janker Klinik & University of Bonn Medical Center, Bonn, Germany.
  • Slotman BJ; Department of Radiation Oncology, Maastro Clinic, Maastricht, The Netherlands.
  • Westerman BA; Department of Radiation Oncology, VU University Medical Center/Cancer Center Amsterdam, P.O. Box 7057, Amsterdam, 1007, MB, The Netherlands.
  • Peters GJ; Department of Neurosurgery, Neuro Oncology Research Group, VU University Medical Center, Amsterdam, The Netherlands.
  • Sminia P; Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands.
BMC Cancer ; 17(1): 204, 2017 03 21.
Article en En | MEDLINE | ID: mdl-28320338
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Esferoides Celulares / Proteínas Proto-Oncogénicas c-akt / Compuestos Heterocíclicos con 3 Anillos Límite: Humans Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Esferoides Celulares / Proteínas Proto-Oncogénicas c-akt / Compuestos Heterocíclicos con 3 Anillos Límite: Humans Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos