Endogenous prostaglandin E2 amplifies IL-33 production by macrophages through an E prostanoid (EP)2/EP4-cAMP-EPAC-dependent pathway.

Samuchiwal, Sachin K; Balestrieri, Barbara; Raff, Hannah; Boyce, Joshua A

Endogenous prostaglandin E₂ amplifies IL-33 production by macrophages through an E prostanoid (EP)₂/EP₄-cAMP-EPAC-dependent pathway.

Samuchiwal, Sachin K; Balestrieri, Barbara; Raff, Hannah; Boyce, Joshua A.

Afiliación

Samuchiwal SK; Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts 02115; Harvard Medical School, Boston, Massachusetts 02115.
Balestrieri B; Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts 02115; Harvard Medical School, Boston, Massachusetts 02115.
Raff H; Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts 02115.
Boyce JA; Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts 02115; Harvard Medical School, Boston, Massachusetts 02115. Electronic address: jboyce@rics.bwh.harvard.edu.

J Biol Chem ; 292(20): 8195-8206, 2017 05 19.

Article en En | MEDLINE | ID: mdl-28341741

Asunto(s)

AMP Cíclico/metabolismo; Dinoprostona; Factores de Intercambio de Guanina Nucleótido/metabolismo; Interleucina-33/metabolismo; Macrófagos/metabolismo; Subtipo EP2 de Receptores de Prostaglandina E/metabolismo; Subtipo EP4 de Receptores de Prostaglandina E/metabolismo; Animales; AMP Cíclico/genética; Dinoprostona/metabolismo; Dinoprostona/farmacología; Factores de Intercambio de Guanina Nucleótido/genética; Interleucina-33/genética; Lipopolisacáridos/toxicidad; Ratones; Ratones Mutantes; Prostaglandina-E Sintasas/genética; Prostaglandina-E Sintasas/metabolismo; Subtipo EP2 de Receptores de Prostaglandina E/genética; Subtipo EP4 de Receptores de Prostaglandina E/genética

Palabras clave

EPAC; IL-33; PGE2; bone marrow macrophages; cAMP; cytokine; innate immunity; mPGES-1; macrophage; prostaglandin

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Dinoprostona / AMP Cíclico / Factores de Intercambio de Guanina Nucleótido / Subtipo EP2 de Receptores de Prostaglandina E / Subtipo EP4 de Receptores de Prostaglandina E / Interleucina-33 / Macrófagos Límite: Animals Idioma: En Revista: J Biol Chem Año: 2017 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google