Novel pyrazolo[1,5-a]pyridines as orally active EP<sub>1</sub> receptor antagonists: Synthesis, structure-activity relationship studies, and biological evaluation.

Umei, Kentaro; Nishigaya, Yosuke; Kondo, Atsushi; Tatani, Kazuya; Tanaka, Nobuyuki; Kohno, Yasushi; Seto, Shigeki

Novel pyrazolo[1,5-a]pyridines as orally active EP₁ receptor antagonists: Synthesis, structure-activity relationship studies, and biological evaluation.

Umei, Kentaro; Nishigaya, Yosuke; Kondo, Atsushi; Tatani, Kazuya; Tanaka, Nobuyuki; Kohno, Yasushi; Seto, Shigeki.

Afiliación

Umei K; Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan.
Nishigaya Y; Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan.
Kondo A; Central Research Laboratories, Kissei Pharmaceutical Co., Ltd., 4365-1, Kashiwabara, Hotaka, Azumino, Nagano 399-8304, Japan.
Tatani K; Central Research Laboratories, Kissei Pharmaceutical Co., Ltd., 4365-1, Kashiwabara, Hotaka, Azumino, Nagano 399-8304, Japan.
Tanaka N; Central Research Laboratories, Kissei Pharmaceutical Co., Ltd., 4365-1, Kashiwabara, Hotaka, Azumino, Nagano 399-8304, Japan.
Kohno Y; Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan.
Seto S; Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Electronic address: shigeki.seto@mb.kyorin-pharm.co.jp.

Bioorg Med Chem ; 25(9): 2635-2642, 2017 05 01.

Article en En | MEDLINE | ID: mdl-28342692

Asunto(s)

Pirazoles/uso terapéutico; Piridinas/uso terapéutico; Subtipo EP1 de Receptores de Prostaglandina E/antagonistas & inhibidores; Animales; Línea Celular; Masculino; Pirazoles/síntesis química; Pirazoles/farmacocinética; Piridinas/síntesis química; Piridinas/farmacocinética; Ratas Wistar; Relación Estructura-Actividad; Vejiga Urinaria Hiperactiva/tratamiento farmacológico

Palabras clave

EP(1) antagonist; Matched molecular pair; Pyrazolo[1,5-a]pyridine; Structure-activity relationships

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Pirazoles / Piridinas / Subtipo EP1 de Receptores de Prostaglandina E Límite: Animals Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Japón

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