T1-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis.
Nanomaterials (Basel)
; 5(4): 1880-1890, 2015 Nov 04.
Article
en En
| MEDLINE
| ID: mdl-28347101
ABSTRACT
Iron oxide nanoparticles have long been studied as a T2 contrast agent in MRI due to their superparamagnetic behavior. T1-based positive contrast, being much more favorable for clinical application due to brighter and more accurate signaling is, however, still limited to gadolinium- or manganese-based imaging tools. Though being the only available commercial positive-contrast agents, they lack an efficient argument when it comes to biological toxicity and their circulatory half-life in blood. The need arises to design a biocompatible contrast agent with a scope for easy surface functionalization for long circulation in blood and/or targeted imaging. We hereby propose an extremely fast microwave synthesis for fluorescein-labeled extremely-small iron oxide nanoparticles (fdIONP), in a single step, as a viable tool for cell labeling and T1-MRI. We demonstrate the capabilities of such an approach through high-quality magnetic resonance angiographic images of mice.
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MEDLINE
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En
Revista:
Nanomaterials (Basel)
Año:
2015
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Article
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España