The ketogenic diet metabolite beta-hydroxybutyrate (ß-HB) reduces incidence of seizure-like activity (SLA) in a K<sub>atp</sub>- and GABA<sub>b</sub>-dependent manner in a whole-animal Drosophila melanogaster model.

Li, Jinglu; O'Leary, Emma I; Tanner, Geoffrey R

The ketogenic diet metabolite beta-hydroxybutyrate (ß-HB) reduces incidence of seizure-like activity (SLA) in a K_atp- and GABA_b-dependent manner in a whole-animal Drosophila melanogaster model.

Li, Jinglu; O'Leary, Emma I; Tanner, Geoffrey R.

Afiliación

Li J; Department of Biological Sciences, Mount Holyoke College, South Hadley, MA 01075, United States; Program in Neuroscience and Behavior, Mount Holyoke College, South Hadley, MA 01075, United States.
O'Leary EI; Department of Biological Sciences, Mount Holyoke College, South Hadley, MA 01075, United States; Program in Biochemistry, Mount Holyoke College, South Hadley, MA 01075, United States.
Tanner GR; Department of Biological Sciences, Mount Holyoke College, South Hadley, MA 01075, United States; Program in Neuroscience and Behavior, Mount Holyoke College, South Hadley, MA 01075, United States; Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, United States; Connecticut Institute for the Brain and Cognitive Sciences, United States. Electronic address: geoffrey.tanner@uconn.edu.

Epilepsy Res ; 133: 6-9, 2017 07.

Article en En | MEDLINE | ID: mdl-28395176

Asunto(s)

Ácido 3-Hidroxibutírico/uso terapéutico; Anticonvulsivantes/uso terapéutico; Antagonistas del GABA/farmacología; Canales KATP/metabolismo; Receptores de GABA-B/metabolismo; Convulsiones/tratamiento farmacológico; Animales; Animales Modificados Genéticamente; Modelos Animales de Enfermedad; Proteínas de Drosophila/genética; Drosophila melanogaster; Hipoglucemiantes/farmacología; Canales KATP/genética; Ácidos Fosfínicos/farmacología; Propanolaminas/farmacología; Receptores de GABA-B/genética; Transducción de Señal/efectos de los fármacos; Estadísticas no Paramétricas; Tolbutamida/farmacología

Palabras clave

Bang sensitive; GABA(b) receptor; K(atp) channel; Ketogenic diet; Ketone bodies; Seizure model

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Convulsiones / Receptores de GABA-B / Antagonistas del GABA / Ácido 3-Hidroxibutírico / Canales KATP / Anticonvulsivantes Tipo de estudio: Incidence_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Epilepsy Res Asunto de la revista: CEREBRO / NEUROLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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