Establishment of MUi009 - A human induced pluripotent stem cells from a 32year old male with homozygous ß°-thalassemia coinherited with heterozygous α-thalassemia 2.
Stem Cell Res
; 20: 80-83, 2017 04.
Article
en En
| MEDLINE
| ID: mdl-28395745
ABSTRACT
The thalassemias are a group of genetic disorders characterized by a deficiency in the synthesis of globin chains. In this study the MUi009-A human induced pluripotent stem cell line was successfully generated from peripheral blood CD34+ haematopoietic progenitors of a 32year old male who had coinherited a homozygous ß°-thalassemia mutation at codon 41/42 (-TCTT) and a heterozygous α-thalassemia 4.2 deletion. The MUi009-A cell line exhibited embryonic stem cell characteristics with consistent pluripotency marker expression and the capability of differentiating into the three germ layers. The cell line may provide a tool for drug testing and gene therapy studies.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Talasemia alfa
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Reprogramación Celular
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Células Madre Pluripotentes Inducidas
Límite:
Adult
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Humans
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Male
Idioma:
En
Revista:
Stem Cell Res
Año:
2017
Tipo del documento:
Article
País de afiliación:
Tailandia