Recent advances in peptide nucleic acid for cancer bionanotechnology.
Acta Pharmacol Sin
; 38(6): 798-805, 2017 Jun.
Article
en En
| MEDLINE
| ID: mdl-28414202
ABSTRACT
Peptide nucleic acid (PNA) is an oligomer, in which the phosphate backbone has been replaced by a pseudopeptide backbone that is meant to mimic DNA. Peptide nucleic acids are of the utmost importance in the biomedical field because of their ability to hybridize with neutral nucleic acids and their special chemical and biological properties. In recent years, PNAs have emerged in nanobiotechnology for cancer diagnosis and therapy due to their high affinity and sequence selectivity toward corresponding DNA and RNA. In this review, we summarize the recent progresses that have been made in cancer detection and therapy with PNA biotechnology. In addition, we emphasize nanoparticle PNA-based strategies for the efficient delivery of drugs in anticancer therapies.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Biotecnología
/
Ácidos Nucleicos de Péptidos
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Nanomedicina
/
Neoplasias
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Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Acta Pharmacol Sin
Asunto de la revista:
FARMACOLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
China