Nerve Growth Factor and Pain Mechanisms.
Annu Rev Neurosci
; 40: 307-325, 2017 07 25.
Article
en En
| MEDLINE
| ID: mdl-28441116
ABSTRACT
Nerve growth factor (NGF) antagonism is on the verge of becoming a powerful analgesic treatment for numerous conditions, including osteoarthritis and lower back pain. This review summarizes the historical research, both fundamental and clinical, that led to our current understanding of NGF biology. We also discuss the surprising number of questions that remain about NGF expression patterns and NGF's various functions and interaction partners in relation to persistent pain and the potential side effects of anti-NGF therapy.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Dolor
/
Receptor trkA
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Factor de Crecimiento Nervioso
/
Receptor de Factor de Crecimiento Nervioso
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Neurosci
Año:
2017
Tipo del documento:
Article