How and why do T cells and their derived cytokines affect the injured and healthy brain?
Nat Rev Neurosci
; 18(6): 375-384, 2017 06.
Article
en En
| MEDLINE
| ID: mdl-28446786
ABSTRACT
The evolution of adaptive immunity provides enhanced defence against specific pathogens, as well as homeostatic immune surveillance of all tissues. Despite being 'immune privileged', the CNS uses the assistance of the immune system in physiological and pathological states. In this Opinion article, we discuss the influence of adaptive immunity on recovery after CNS injury and on cognitive and social brain function. We further extend a hypothesis that the pro-social effects of interferon-regulated genes were initially exploited by pathogens to increase host-host transmission, and that these genes were later recycled by the host to form part of an immune defence programme. In this way, the evolution of adaptive immunity may reflect a host-pathogen 'arms race'.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Lesiones Encefálicas
/
Linfocitos T
/
Citocinas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos