Increased Level of Serum Hepcidin in Female Adolescent Athletes.
Clin J Sport Med
; 28(2): 180-183, 2018 03.
Article
en En
| MEDLINE
| ID: mdl-28452831
ABSTRACT
OBJECTIVE:
To determine the serum hepcidin concentration and standard hematological parameters in a group of female adolescent athletes, compared with a group of nonathlete females.DESIGN:
A case-control study.SETTING:
A senior high school for athletes in Gothenburg, Sweden.PARTICIPANTS:
All female athletes (70), at the school were offered to take part. Fifty-six athletes accepted. From a random sample of age-matched nonathletes, 71 students were recruited to the control group. MAIN OUTCOMEMEASURES:
Iron deficiency (ID) was determined by levels of serum iron, total iron-binding capacity, transferrin saturation (TS), and ferritin. Serum hepcidin was determined by a mass spectrometry method. All samples were taken at least 12 hours after training.RESULTS:
The main result was the finding of a significantly elevated serum hepcidin level in the athlete group, 4.7 nmol/L compared with 3.3 nmol/L (P < 0.001) in the nonathlete group. In the athlete group, the serum iron concentration was significantly lower, 14.0 µmol/L compared with 17.6 µmol/L (P = 0.003) in the nonathlete group. No difference was found regarding TS, total iron binding capacity, and ferritin. There was no difference in the occurrence of ID or iron deficiency anaemia (IDA).CONCLUSIONS:
These findings show an increase in serum hepcidin in a large group of female athletes. The elevated hepcidin levels may affect the iron balance of the athletes, adding to the traditional explanation of dietary intake/iron loss balance.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Atletas
/
Hepcidinas
/
Hierro
Tipo de estudio:
Observational_studies
Límite:
Adolescent
/
Female
/
Humans
Idioma:
En
Revista:
Clin J Sport Med
Asunto de la revista:
MEDICINA ESPORTIVA
Año:
2018
Tipo del documento:
Article