Characterization of circulating pro-opiomelanocortin-related peptides in human septic shock.
J Endocrinol
; 119(1): 159-65, 1988 Oct.
Article
en En
| MEDLINE
| ID: mdl-2848089
ABSTRACT
The nature of circulating pro-opiomelanocortin (POMC)-related peptides was investigated in patients with a diagnosis of septic shock. Also, changes following administration of methylprednisolone were monitored using established chromatographic techniques and three radioimmunoassays directed towards the N-terminal, mid-portion and C-terminal regions of the precursor. Adrenocorticotrophin and beta-endorphin-like peptides were identified in the circulation. By 60 min after a pharmacological dose of methylprednisolone (30 mg/kg) concentrations of these peptides were reduced and continued to fall up to 180 min. beta-Lipotrophin and N-terminal POMC(1-76) were also detected by the beta-endorphin and gamma 3-MSH assays respectively. The concentrations of these peptides were noticeably reduced only after 180 min. The 31,000 Da MSH/ACTH/beta-endorphin (POMC) and the 22,000 Da MSH/ACTH precursors were also present in the circulation in septic shock and their concentrations increased following steroid treatment.
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Bases de datos:
MEDLINE
Asunto principal:
Péptidos
/
Choque Séptico
/
Proopiomelanocortina
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Endocrinol
Año:
1988
Tipo del documento:
Article