The Sleeping Remnant. Effect of Roux-En-Y Gastric Bypass on Plasma Levels of Gastric Biomarkers in Morbidly Obese Women: A Prospective Longitudinal Study.
Obes Surg
; 27(7): 1901-1905, 2017 07.
Article
en En
| MEDLINE
| ID: mdl-28508274
ABSTRACT
BACKGROUND:
Morpho-functional modifications of the gastric remnant after Roux-en-Y gastric bypass (RYGB) have not been completely defined, due to its inaccessibility for bioptic mapping. The aim of the study is to evaluate such modifications using Gastropanel®, a non-invasive blood test cross-checking four gastric biomarkers, able to provide a snapshot of mucosa conditions. SUBJECTS ANDMETHODS:
Twenty-four women undergoing RYGB were prospectively enrolled. Gastropanel® parameters (pepsinogens, Gastrin-17 and immunoglobulins against Helicobacter pylori), biometrical/clinical data were collected preoperatively and at 6-months follow-up.RESULTS:
All parameters showed significant reduction (p < 0.05). Pepsinogen I reduction correlated with BMI percent decrease.CONCLUSIONS:
The exclusion of food transit is responsible for significant drop in gastric output, hardly representing a risk factor in the remnant carcinogenesis, being unexposed to alimentary carcinogenic agents.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Pepsinógenos
/
Obesidad Mórbida
/
Inmunoglobulina G
/
Gastrinas
/
Muñón Gástrico
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Obes Surg
Asunto de la revista:
METABOLISMO
Año:
2017
Tipo del documento:
Article
País de afiliación:
Italia